25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias

25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias

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Abstract It has been shown that there is a decrease in the concentrations of 25 hydroxyvitamin D (25-OHD) and bone mineral density (BMD) in patients ds durga hand soap with phenylketonuria (PKU) in their follow-up.Our objective was to determine concentrations of 25-OHD in subjects with PKU and hyperphenylalaninemia (HPA).Transversal analytical study considered three groups: G1-PKU with neonatal diagnosis and formula intake without Phe; G2-HPA, without specific treatment and G3-C control group.

Sixteen patients per group (aged 6-23) were included.Levels of 25-OHD, lumbar spine (L2-L4), femur and total BMD, intact parathormone (PTH) and vitamin D (VitD) and calcium intake were calculated.The Kruskal-Wallis statistical test was applied (p-value30 ng/mL).

G1-PKU had a higher intake of VitD, with differences among groups.There were no significant differences among groups in relation to BMD and intact PTH.In conclusion, G1-PKU under treatment and with good adherence, does not us polo assn mens sweaters present VitD deficiency and no BMD alterations are observed.

In contrast, G2-HPA had a lower intake of VitD and decreased 25-OHD concentrations which could affect the bone architecture in the long term.Further studies on the G2-HPA are suggested.